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Saturday, November 24, 2007

 

Schizophrenia: The Curse That’s Almost a Blessing

‘New research is pointing to a different possibility: There may be no adaptive advantage provided by schizophrenia in and of itself, but rather from some genes that contribute to the disease. According to a study published in the Proceedings of the Royal Society, there is evidence that some of the gene variants associated with schizophrenia—especially a mutation in a gene called disrupted-in-schizophrenia 1 (DISC1)—have been selected for by evolution. This supports the idea that the disease may be a maladaptive combination of mutations that individually have the potential to enhance fitness. It could be a more complicated version of the familiar case of sickle cell anemia: having two mutant copies of a certain gene causes the disease, whereas having only one mutant copy provides protection against malaria.’




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